The following information addresses central line-associated bloodstream infection (CLABSI) in general.
FLEXBUMIN® [Albumin (Human)] has not been evaluated in clinical studies for CLABSI risk reduction.
Closed Infusion Systems and Prevention of Hospital-Acquired Infection
CLABSIS ARE A WIDESPREAD CLINICAL PROBLEM, POSING A SIGNIFICANT ECONOMIC IMPACT ON HEALTHCARE INSTITUTIONS1,2*
About
30,000 to 40,000
CASES STILL OCCUR IN THE US ANNUALLY1
Estimated Cost per Event (95% CI)
$55,154.26
($31,220.61–$79,086.77)2
Median Estimated Annual Cost per Hospital (95% CI)
$220,617
($124,882–$316,347)2
*Study was conducted from January 2016 to December 2022 at 45 hospitals affiliated with the Duke Infection Control Outreach Network (DICON). Study used per-HAI-case additional cost-point estimates scaled to the 2021 US dollar. These estimates represent the incremental cost to the hospital of the inpatient stay that is attributable to the HAI of interest.2
CLOSED INFUSION SYSTEM MAY REDUCE RISK OF CLABSI3
According to the Joint Commission, use of closed infusion systems that lower risk for contamination during initial setup and administration may help to further reduce the risk for CLABSI. The Joint Commission has defined open and closed systems as follows:
CLOSED INFUSION SYSTEMS
IV fluid containers that require no external venting for the bag to empty are closed infusion systems.
OPEN INFUSION SYSTEMS
Glass bottles, semi-rigid plastic bottles, and burettes that must be vented to allow air to enter for the fluid to egress are open infusion systems.
References
- Odada D, Munyi H, Gatuiku J, et al. Reducing the rate of central line-associated bloodstream infections; a quality improvement project. BMC Infect Dis. 2023;23:745.
- Zhang HL, Crane L, Cromer AL, et al. A 7-year analysis of attributable costs of healthcare-associated infections in a network of community hospitals in the southeastern United States. Infect Control Hosp Epidemiol. 2024;45(1):103-105.
- The Joint Commission. Preventing Central Line-Associated Bloodstream Infections: A Global Challenge, a Global Perspective. Accessed March 3, 2025. Available at: https://www.jointcommission.org/-/media/tjc/documents/resources/hai/